Photoadditions of Silyl Butadienyl Ether to 1,2-Diketones
نویسندگان
چکیده
منابع مشابه
Asymmetric Electrophilic α-Amination of Silyl Enol Ether Derivatives via the Nitrosocarbonyl Hetero-ene Reaction.
The first example of a general asymmetric nitrosocarbonyl hetero-ene reaction is described. The procedure uses a copper-catalyzed aerobic oxidation of a commercially available chiral nitrosocarbonyl precursor (EleNOr) and is operationally simple. The transformation is both high yielding and highly diastereoselective for a range of silyl enol ether derivatives. A variety of synthetically useful ...
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A diastereoselective synthesis of cis-2,6-disubstituted tetrahydropyran-4-ones was developed. The key step of this methodology, a silyl enol ether Prins cyclization, was promoted by a condensation reaction between a hydroxy silyl enol ether and an aldehyde to afford substituted tetrahydropyran-4-ones. The cyclization was tolerant of many functional groups, and the modular synthesis of the hydro...
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For an improved synthesis of the recently described expanded octamethoxycubane with a central C56 core, formally obtained by inserting buta-1,3-diynediyl moieties into all C(sp3)-C(sp3) bonds of octamethoxycubane, the preparation of the optically pure methyl ether of a differentially silyl-protected trispropargylic alcohol was required. The key step of the preparation involved a diastereoselect...
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[reaction: see text] Herein we report a new set of silyl ether reagents for determining the enantiomeric purity and absolute stereochemistry of secondary alcohols. These derivatives are easily synthesized, provide straightforward spectroscopic results, and allow for facile recovery of the original chiral alcohol.
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Delivery systems designed to have triggered release after passively targeting the tumor may improve small molecule chemotherapeutic delivery. Particle replication in nonwetting templates was used to prepare nanoparticles to passively target solid tumors in an A549 subcutaneous xenograft model. An acid labile prodrug was delivered to minimize systemic free docetaxel concentrations and improve to...
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ژورنال
عنوان ژورنال: Journal of the Korean Chemical Society
سال: 2013
ISSN: 1017-2548
DOI: 10.5012/jkcs.2013.57.1.9